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Common gastrointestinal manifestations include nausea, vomiting, abdominal pains or cramps, and diarrhea.Although symptoms vary between acute allergy patients, onset generally occurs seconds to minutes after exposure to an allergen and requires prompt treatment.One to 2% of people receiving IV radiocontrast experience some sort of reaction.The majority of these reactions are minor, and fatalities are rare. The true incidence of acute allergic reactions is unknown, partly because of the lack of a precise definition of the syndrome.Some clinicians reserve the term anaphylaxis for the full-blown syndrome, while others use it to describe milder cases.
Fewer than 100 fatal reactions to Hymenoptera stings are reported each year in the United States, but this is considered to be an underestimate.In particular, an intravenous injectable is disclosed as are methods of treating acute allergic reactions therewith. The immune system activates immunoglobulin E (Ig E), which reacts with effector cells (mast cells and basophils).NON-SEDATING ANTIHISTAMINE INJECTION FORMULATIONS AND METHODS OF USE THEREOF CROSS REFERENCE TO RELATED APPLICATION  This application claims priority to U. These cells, in turn, release histamine, serotonin, leukotrienes, and prostaglandins, and induce a range of signs and symptoms, such as facial flushing, urticaria (hives), angioedema, pruritus, erythema, wheezing, bronchoconstriction, cough, cardiac arrhythmias, hypotension, nausea, vomiting, and diarrhea.Elderly persons have the greatest risk of mortality from acute allergic reactions due to the presence of preexisting disease.
 Emergency treatment includes airway protection, alpha-agonists, antihistamines, steroids, and beta agonists.
Accordingly, new treatments for acute allergic reactions are needed, particularly for use in the emergency setting.